| 1845–1958 | Germany [earth sciences] | German naturalist and explorer Alexander von Humboldt lays the basis of modern geography with the publication of Kosmos/Cosmos, in which he arranges geographic knowledge in a systematic fashion. |
| 1921 | [fiction] | The English writer D H Lawrence publishes his novel Women in Love. It was privately published in the USA in 1920. |
| 1921 | [fiction] | The Italian writer Italo Svevo publishes his novel La coscienza di Zeno/The Confessions of Zeno. |
| 1921 | [cinema and film] | The film Dream Street, directed by D W Griffith, is released in the USA, starring Tyrone Power, Sr, Ralph Graves, and Carol Dempster. It is the first to feature some singing and dialogue, supplied on synchronized records. |
| 1921 | Canada [medicine] | Canadian physiologists Frederick Banting, Charles Best, and John James MacLeod isolate insulin. A diabetic patient in Toronto, Canada, receives the first insulin injection. |
| 1921 | [physics] | German physicist Max Born develops a mathematical description of the first law of thermodynamics. |
| 1921 | Italy [plays] | The play Sei personaggi in cerca d'autore/Six Characters in Search of an Author, by the Italian writer Luigi Pirandello, is first performed, in Rome, Italy. |
| 1921 | Czechoslovakia [plays] | The play R U R: Rossum's Universal Robots, by the Czech writer Karel Capek, is first performed, in Prague, Czechoslovakia. It popularizes the word ‘robot’, from the Czech word ‘robota’, meaning ‘compulsory labour’. |
| 1921 | [poetry] | The Irish writer W B Yeats publishes his poetry collection Michael Robartes and the Dancer, which includes ‘Easter 1916’ and ‘The Second Coming’. |
| 1921 | [psychology] | Swiss psychologist Carl Jung publishes Psychologische Typen/Psychological Types, in which he differentiates two personality types: extroverted and introverted. |
| 1921 | USA [public health] | The death rate in the USA is 1,163.9 per 100,000 population, compared with 1,755 in 1900. |
| 1921 | Russia [political events] | Five million people die in a famine in the Volga region of Russia, a consequence of Bolshevik food requisitioning policies and drought. |
| 1921 | [solo and chamber music] | The English composer William Walton completes his ‘entertainment’ Façade for voices and chamber ensemble. It consists of settings of poems by the English writer Edith Sitwell. |
| 1921 | Germany [other structures] | The Einstein Tower in Potsdam, Germany, designed by the German architect Erich Mendelssohn, is completed, one of the finest examples of expressionist architecture. |
| 1921 | USA [technology] | US physicist Albert Hull invents the magnetron, an oscillator that generates microwaves. |
| 19 February 1921 | USA [transport] | The US Red Cross announces that 20,000 children die in automobile accidents each year. |
| 25 February 1921 | Georgia, Russia [political events] | A Bolshevik government is established in the republic of Georgia. |
| 28 February - 17 March 1921 | Russia [political events] | A mutiny of sailors begins at Kronstadt naval base near Petrograd, Russia, in opposition to the communist government's harsh policies; it is put down by troops. |
| 17 March 1921 | Russia [political events] | At the 10th Congress of the Russian Communist Party, the Russian leader Vladimir Ilyich Lenin introduces his New Economic Policy, which restores some private business and freedom of trade; the forcible requisition of grain has led to famine and revolts. |
| 2 April 1921 | Armenia, Russia [political events] | A Bolshevik government is established in the republic of Armenia. |
| 23 April 1921 | Romania [political events] | Through a Czechoslovak-Romanian alliance Romania joins the ‘Little Entente’ (a defensive alliance of eastern European nations). |
| 24 April 1921 | Kingdom of the Serbs Croats and Slovenes, Italy [political events] | The northern Adriatic port of Fiume (Rijeka), disputed between Italy and the Kingdom of the Serbs, Croats, and Slovenes, votes to become a free city. |
| 5 May 1921 | France [clothing and fashion] | Chanel No. 5 perfume, created by perfumer Ernst Beaux, is launched. |
| 19 May 1921 | USA [work and unemployment] | The University of Chicago announces that the average college graduate earns $5,762 per year after ten years of work. |
| 21 May 1921 | [births and deaths] | Andrey Dimitriyevich Sakharov, Soviet nuclear physicist and outspoken supporter of human rights and civil liberties, born in Moscow, Russia (–1989). |
| 7 June 1921 | Romania, Kingdom of the Serbs Croats and Slovenes [political events] | An alliance is made between Romania and the Kingdom of the Serbs, Croats, and Slovenes, completing Romania's entry into the ‘Little Entente’ (a defensive alliance of eastern European nations). |
| 2 July 1921 | USA, France [boxing] | In the first ever boxing match to gross over a million dollars, more than 80,000 people in a purpose-built wooden stadium in Jersey City, USA, watch the defending US champion Jack Dempsey knock out George Carpentier of France in four rounds to retain his world heavyweight boxing title. |
| 9 July 1921 | United Kingdom [political events] | The Irish nationalist leader Eamon de Valera, on behalf of the self-declared Irish Republic, agrees a truce with the British authorities (fighting ends two days later). |
| 21 July 1921 | Spain, Morocco [wars] | Spanish troops under General Fernandez Silvestre waging a campaign against the Riffians in Morocco are defeated by troops led by Abd al-Karim; 12,000 are killed. |
| 5 November 1921 | Russia, Mongolia [treaties] | A treaty of alliance is signed between the communist governments of Mongolia and Russia following the defeat of anticommunist White Russian forces under Roman von Ungern-Sternberg. |
| 5 November 1921 | USA [everyday life] | The US president Warren G Harding declares Armistice Day (November 11, the date of the end of World War I in 1918) a national holiday. |
| 11 November 1921 | USA [World War I (1914–18)] | The Unknown Soldier, whose body has been lying in state in the Capitol rotunda in Washington, DC, is buried at Arlington National Ceremony, Virginia, as a memorial to all other unidentified US soldiers killed in World War I. |
| 27 November 1921 | [births and deaths] | Alexander Dubcek, Czechoslovak communist leader 1968–69 whose liberal policies led to the Soviet occupation of Czechoslovakia (now the Czech and Slovak Republics), born in Uhrovec, Slovakia (–1992). |
| 6 December 1921 | United Kingdom [treaties] | The British government and representatives of the Dáil Eireann sign the Anglo-Irish Treaty providing for an independent southern Ireland with dominion status (within the British Empire). |
| 29 December 1921 | Canada [political events] | Following the defeat of the Conservatives in the Canadian general election, the Liberal leader Mackenzie King is appointed prime minister and governs with support from the Progressives. |