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tissue plasminogen activator
(redirected from Alteplase)

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tissue plasminogen activator

Naturally occurring substance in the body tissues that activates the enzyme plasmin that is able to dissolve blood clots. Human tPA, produced in bacteria by genetic engineering, has, like streptokinase, been used to dissolve blood clots in the coronary arteries of heart-attack victims. It has been shown to be more effective than streptokinase when used in conjunction with heparin, but it is much more expensive.



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Alteplase is a tissue plasminogen activator enzyme that binds to fibrin in a thrombus and converts the plasminogen to plasmin, initiating fibrinolysis.
Patients across the town suffering an attack will now be able to get clot-busting drug Alteplase along with thrombolysis treatment at their local hospital day and night.
Ishemic stroke patients with an area of hypoperfusion larger than the area of infarct and cytotoxic damage may still benefit from alteplase 3-6 hours after stroke onset, according to a study presented at the International Stroke Conference 2008 in New Orleans.
 
 
 
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