Patients often exhibit congenital anomalies that include limb defects; reduction deformity of the arms and forearms; no digits or missing digits on the hands; reduction deformity of the legs; hind legs; no digits or missing digits on the feet; spinal dysraphism; congenital diaphragmatic hernia; lung hypoplasia or lung agenesis; thoracopagus; micrognathia; microgastria; craniostenostosis; anal atresia or anal stenosis; hypoplasia; and, polysplenia.

In addition, the data "suggested" possible links between sertraline and both anal atresia and limb-reduction defects, and possible links between paroxetine and both neural-tube defects and clubfoot.

Introduction The association among coloboma iridis, auricular deformity, and anal atresia was first described by Haab in 1879.