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BCG
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BCG

Abbreviation for bacille Calmette-Guérin, bacillus injected as a vaccine to confer active immunity to tuberculosis (TB).

BCG was developed by Albert Calmette and Camille Guérin in France in 1921 from live bovine TB bacilli. These bacteria were bred in the laboratory over many generations until they became attenuated (weakened). Each inoculation contains just enough live, attenuated bacilli to provoke an immune response: the formation of specific antibodies. The vaccine provides protection for 50–80% of infants vaccinated. It is effective for a decade but then wears off; booster shots are ineffective.



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? Mentioned in ? References in periodicals archive
 
Methodological considerations in case-control studies to evaluate BCG vaccine effectiveness.
Risk factors for Buruli ulcer, Benin by Dramaix, Michele / Emerging Infectious Diseases
The scientists gave the new vaccine to 17 volunteers who had received the BCG vaccine in the past--as recently as within a year or as long as 38 years ago.
TB vaccine gets a needed boost by Science News
Although the BCG vaccine offers protection against the most serious forms of TB in childhood, its efficacy wanes over a period of 10-15 years after the vaccination.
AERAS/CRUCELL TO DEVELOP TB VACCINE by Worldwide Biotech
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