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Borna disease virus

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Borna disease virus

Disease-causing virus that consists of a single strand of RNA and is distantly related to the rabies virus. It affects a wide range of animals, causing behavioural changes such as increased aggression and excitability. It is fatal in horses.

The virus or antibodies directed against it have been discovered in patients suffering from psychiatric conditions such as depression and obsessive-compulsive disorder. However, a causal link between the virus and these disorders has not yet been proven.



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Borna disease virus (BDV) is the causative agent of severe T-cell-mediated meningoencephalitis in horses, sheep, and other animal species in central Europe.
Shrews as reservoir hosts of Borna disease virus by Ehrensperger, Felix / Emerging Infectious Diseases
The alleged culprit, Borna disease virus (BDV), was first reported more than 100 years ago to cause a neurological disease of horses in Borna, Germany.
Virus may trigger some mood disorders by Bower, Bruce / Science News
These included hepatitis E virus, with similar strains causing liver disease in swine and humans; Borna disease virus, causing neurologic disease in various species of animals as well as, debatably, psychiatric disorders in humans; and the recently discovered severe acute respiratory syndrome-associated coronavirus and its yet-undefined animal reservoir.
Vets, meds, and zoonotic threats by Pitlik, Silvio / Emerging Infectious Diseases
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