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genetic code |
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genetic codeWay in which instructions for building proteins, the basic structural molecules of living matter, are ‘written’ in the genetic material DNA. This relationship between the sequence of bases (the subunits in a DNA molecule) and the sequence of amino acids (the subunits of a protein molecule) is the basis of heredity. The code employs codons of three bases each; it is the same in almost all organisms, except for a few minor differences recently discovered in some protozoa. Following the discovery of the DNA double helix in 1953, which suggested that the sequence of nucleobases along the DNA strand encoded the amino acid sequence of proteins in some way, it took researchers more than a decade to ‘decipher’ the code. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The major polymorphisms associated with susceptibility or resistance are located at codons 136 (A or V), 154 (R or H), and 171 (R, Q, of H) (3,4). Biologists have long held that swapping one codon for another doesn't change the resulting protein's structure, as long as both codons instruct the machinery to insert the same amino acid. The sequence of the cloned DNA shows that SeP contains 10 Sec groups encoded by UGA stop codons in the open reading frame of its mRNA (Burk et al. |
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