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resistance |
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resistanceIn physics, that property of a conductor that restricts the flow of electricity through it, associated with the conversion of electrical energy to heat; also the magnitude of this property. Materials that are good conductors of electricity have electrons held loosely in the outer shells of their atoms. Current can flow easily and these materials have low resistance. In poor conductors of electricity, the electrons in the outer shells of their atoms are more strongly attracted by the positively-charged nucleus. Such materials restrict the flow of electrons and have a high resistance. Resistance (R) is related to current (I) and voltage (V) by the formula: R = V/I. The statement that current is proportional to voltage (resistance is constant) at constant temperature is known as Ohm's law. It is approximately true for many materials that are accordingly described as ‘ohmic’. Resistance depends on many factors, such as the nature of the material; its temperature; its length and cross-sectional area; the nature and state of illumination of the surface; and the frequency and magnitude of the current.
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Some of the patients in the trials already had cross resistance to Prezista when the trial began (due to their extensive resistance to other protease inhibitors), and it got worse on the average, as they used the drug--showing the importance of having more than one active antiretroviral, instead of introducing new drugs one by one as they become available, and then often losing them to resistance. The data being presented today support the lack of cross resistance between satraplatin and the two taxanes that are currently approved for use as chemotherapeutic agents in the treatment of human cancers - TAXOTERE and TAXOL," said Marcel Rozencweig, M. In light of the broad sensitivity of human ovarian tumor cell lines to ZD9331 and its lack of cross resistance to platinum based drugs, there is a strong rationale to expect this combination to be effective in treating advanced ovarian cancer patients," said Prof. |
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