Cyclosporin A - Hutchinson encyclopedia article about Cyclosporin A Printer Friendly
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cyclosporin
(redirected from Cyclosporin A)

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cyclosporin

Immunosuppressive drug derived from a fungus (Tolypocladium inflatum). In use by 1978, it revolutionized transplant surgery by reducing the incidence and severity of rejection of donor organs.

It suppresses the T-cells (see lymphocyte) that reject foreign tissue without suppressing other cells that fight infection and cancer.


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Shims group says that survival time is even longer than that of heart-transplant mice treated with cyclosporin A, a drug often used in people receiving organ transplants.
In keeping with this proposed injury mechanism, successful treatment with cyclosporin A has been documented (3).
In vivo expression of IL-4, IL-5, IL-13 and IFN-gamma mRNAs in peripheral blood mononuclear cells and effect of cyclosporin A in a patient with Kimura's disease.
 
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