The sixth edition of this successful textbook newly covers: * Toll-like receptors, their ligands and intracellular activation pathways * The key role of activation induced cytidine deaminase (AID) in somatic hypermutation and class switch recombination * The autoimmune regulator (AIRE) gene in self-tolerance and autoimmunity * T and B cell activation and the immunological synapse, as well as characterization and mechanisms of action of T regulatory cells Key Topics Covered: * About the Authors.

In several different cell lines, it was demonstrated that FMdC is more resistant to cytidine deaminase deactivation than gemcitabine or cytarabine.