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ligand
(redirected from Endogenous ligand)

   Also found in: Medical, Encyclopedia, Wikipedia 0.23 sec.

ligand

In chemistry, a group that bonds to a central atom or ion of a metal; the result is called a coordination complex. An example of a neutral ligand is ammonia; the nitrosyl ion NO+ is a charged ligand. An example of a coordination complex is hexaminocobalt chloride, [Co(NH3)6]Cl3, in which the central cobalt ion (Co3+) is surrounded by covalent bonds with six ammonia molecules and ionic bonds with three chloride ions.

Ligands are used in medicine as an antidote to heavy metal poisoning, removing the metal ions by attaching themselves to form a harmless compound.



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? Mentioned in ? References in periodicals archive
 
The predominance of phytoestrogens as potent agents for ER and NodD signaling further supports the theory that an evolutionarily ancient or ancestral ER may have recognized and responded to phytoestrogens even before the emergence of the natural endogenous ligand [E.
Eight peptides were shown to activate six different GPCRs in a concentration-dependent manner, including some for which there are no known endogenous ligands.
The novel concept of developing allosteric modulators acting on a regulatory site rather than on the endogenous ligand site provides a meaningful way of enhancing the potency of the endogenous ligand and developing compounds with higher specificity and efficacy.
 
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