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ligand |
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ligand
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The predominance of phytoestrogens as potent agents for ER and NodD signaling further supports the theory that an evolutionarily ancient or ancestral ER may have recognized and responded to phytoestrogens even before the emergence of the natural endogenous ligand [E. Eight peptides were shown to activate six different GPCRs in a concentration-dependent manner, including some for which there are no known endogenous ligands. The novel concept of developing allosteric modulators acting on a regulatory site rather than on the endogenous ligand site provides a meaningful way of enhancing the potency of the endogenous ligand and developing compounds with higher specificity and efficacy. |
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