GVHD
| Abbreviation for graft-versus-host disease. |
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GVHD |
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GVHD
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Last year, scientists in Sweden trying a new approach to reverse severe GVHD in 16 patients reported some early success (SN: 12/24/05, p. Upon reexamination 2-3 months after disease induction, autoantibodies characteristic of chronic GVHD were found to have become significantly elevated in surviving iHg-treated mice, but no markers characteristic of iHg-associated autoimmunity were seen. After a marrow transplant, however, holdover Langerhans cells can shift transplant-derived T cells into overdrive, causing inflammation and GVHD reactions, such as skin lesions. |
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