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interferon |
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interferonNaturally occurring cellular protein that makes up part of mammalian defences against viral disease. Three types (alpha, beta, and gamma) are produced by infected cells and enter the bloodstream and uninfected cells, making them immune to virus attack. Interferon was discovered in 1957 by Scottish virologist Alick Isaacs. Interferons are cytokines, small molecules that carry signals from one cell to another. They can be divided into two main types: type I (alpha, beta, tau, and omega) interferons are more effective at bolstering cells' ability to resist infection; type II (gamma) interferon is more important to the normal functioning of the immune system. Alpha interferon may be used to treat some cancers; interferon beta 1b has been found useful in the treatment of multiple sclerosis. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The product, named Locteron(TM), combines OctoPlus' proprietary biodegradable PolyActive(TM) drug delivery technology with Biolex' BLX-883, a recombinant alfa interferon produced in its proprietary LEX System(TM). While the major clinical trials of pegylated interferon and ribavirin show about a 50% success rate in clearing the virus--deemed a sustained virologic response (SVR)--in real-life clinical settings, SVR rates are frequently lower. Complete inhibition of cytopathic effects of SARS-CoV in culture was observed for interferon subtypes, [beta]-1b, [alpha]-n1, [alpha]-n3, and human leukocyte interferon a. |
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