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coagulation |
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coagulation
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| Although the intrinsic pathway involves early activation of caspase-9, and the extrinsic pathway is mediated through caspase-8, both lead to activation of the "executioner" caspase-3 and a variety of proteases and endonucleases. This glycoprotein seems to inhibit the activation of the contact phase system of the intrinsic pathway of blood coagulation (10). TTP889 is the only known selective small molecule inhibitor of Factor IX/IXA, a key enzyme of the intrinsic pathway of the blood coagulation system. |
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