Further south, near the Swiss border, is the town of Konstanz on the shores of Lake Konstanz and the banks of the Rhine River.

1 cycle sequencing kit (Applied Biosystems, Foster City, CA, USA) on an automated ABI 3730 XL capillary sequencer (GATC, Konstanz, Germany).

It allows for experts to be drawn into the discussion and give their opinions rather than be sticking blindfolded to a number," says Evelyn O'Brien, a scientist in the Ecotoxicology Workgroup at the University of Konstanz in Germany and coauthor of a discussion of the draft guideline published in the July 2004 Trends in Biotechnology.