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L-dopa |
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L-dopaChemical, normally produced by the body, which is converted by an enzyme to dopamine in the brain. It is essential for integrated movement of individual muscle groups. L-dopa is a left-handed isomer of an amino acid C9H11NO2. As a treatment, it relieves the rigidity of Parkinson's disease in 60% of sufferers, but may have significant side effects, such as extreme mood changes, hallucinations, and uncontrolled writhing movements. It is often given in combination with other drugs to improve its effectiveness at lower doses. |
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The trials covered Parkinson's disease patients with the wearing-off phenomenon, who have received the treatment with L-DOPA alone or L-DOPA with other agents. A number of studies simply stated diagnosis was confirmed by a neurologist, but most defined a case on the basis of the presence of two or more of the cardinal signs of PD (tremor, rigidity, brady-kinesia, and postural instability); some also used additional criteria, including responsiveness to L-dopa therapy and/or a progressive disorder. Subcortical vascular lesions predict functional recovery after rehabilitation in patients with L-dopa refractory parkinsonism. |
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L-dopa
