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anticoagulant
(redirected from Lupus anticoagulant)

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anticoagulant

Substance that inhibits the formation of blood clots. Common anticoagulants are heparin, produced by the liver and some white blood cells, and derivatives of coumarin, such as warfarin. Anticoagulants are used medically in the prevention and treatment of thrombosis and heart attacks. Anticoagulant substances are also produced by blood-feeding animals, such as mosquitoes, leeches, and vampire bats, to keep the victim's blood flowing.

Most anticoagulants prevent the production of thrombin, an enzyme that induces the formation from blood plasma of fibrinogen, to which blood platelets adhere and form clots.



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? Mentioned in ? References in periodicals archive
 
Lupus anticoagulant is a term used to describe a phenomenon in aPTT testing that occurs when a patient's polyclonal antibodies influence the phospholipid-dependent reaction.
Unidentified coagulation disorders in post-tonsillectomy hemorrhage by Remmert, Stephan / Ear, Nose and Throat Journal
Researchers have now identified two closely related lupus autoantibodies, anticardiolipin antibody and lupus anticoagulant (together called the antiphospholipid antibodies), that are associated with risk of miscarriage.
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Features of APS include hemolytic anemia, thrombocytopenia, venous and arterial occlusions, livedo reticularis, pulmonary manifestations, recurrent fetal loss, neurologic manifestations (stroke, transverse myelitis, Guillain-Barre syndrome); and a positive Coombs test, anticardiolipin antibodies, or lupus anticoagulant activity (1).
Mycoplasma penetrans Bacteremia and Primary Antiphospholipid ... by Cassell, Gail H. / Emerging Infectious Diseases
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