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receptor| In biology, receptors are discrete areas of cell membranes or areas within cells with which neurotransmitters, hormones, and drugs interact. Such interactions control the activities of the body. For example, adrenaline transmits nervous impulses to receptors in the sympathetic nervous system, which initiates the characteristic response to excitement and fear in an individual. |
| Other types of receptors, such as the proprioceptors, are located in muscles, tendons, and joints. They relay information on the position of the body and the state of muscle contraction to the brain. |
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| J Invest Dermatol, 2007, 127, 1250-1260 There are two classes of retinoid receptor, the RAR or retinoic acid receptor, which binds all-transretinoic acid, and RXR, or the so-called orphan receptor whose ligand is believed to be 9-cis-retinoic acid. Topics include the biology of GPRs, their use as targets in cardiovascular drugs and metabolic disease, the possibilities for them in drug history, their use in molecular bioinformatics, their structures and dynamics, crystallization, novel solid-state NMR methods for structural studies, structural genomics, a molecular basis of dimerization, and orphan receptors as promising targets. The agreement allows OSI to access the Cyanamid technology covered in four issued United States patents which include claims for recombinant expression of a variety of targets in yeast, including G-protein coupled receptors, hybrid G-protein coupled receptors and orphan receptors for use in human therapeutics. |
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