Interestingly, SCN5A mutations have been reported to generate several types of disease entities distinct from BS, such as congenital type 3 long-QT syndrome, idiopathic VF, congenital sick sinus syndrome, atrial fibrillation, and even overlap syndrome.

Coverage includes an overview of FTD, basic epidemiological aspects of FTD, clinical and neuropsychiatric features of the three main variants of FTD, FTD-related overlap syndromes, the neuropsychological profile of the condition, neuroimaging and other investigative findings, the histopathology of FTD, molecular neuropathology in familial and sporadic FTD, genetic aspects of the syndrome, and general management, including control of problem behaviors and support for caregivers.

No statistically significant difference was detected between OSAS and overlap syndrome in respect to comorbid diseases (p>0.