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replication
(redirected from Replication fork)

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replication

In biology, production of copies of the genetic material DNA; it occurs during cell division (mitosis and meiosis). Most mutations are caused by mistakes during replication.

During replication the paired strands of DNA separate, exposing the bases. Nucleotides floating in the cell matrix pair with the exposed bases, adenine pairing with thymine, and cytosine with guanine.
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Others have linked sensitivity to low doses of camptothecin to heightened sensitivity of cells in S phase (43) and have provided evidence that camptothecin-induced DSBs resulting from stalled replication forks are resolved by homologous recombination (39, 44).
Human Polynucleotide Kinase Participates in Repair of DNA ... by Feridoun Karimi-Busheri / Biological sciences community
In both cases, fluoroquinolones appear to trap the enzyme on DNA during the topoisomerization reaction, forming a physical barrier to the movement of the replication fork (4), RNA polymerase (5), and DNA helicase (6).
Emerging Mechanisms of Fluoroquinolone Resistance by Hooper, David C. / Emerging Infectious Diseases
The article, "A DNA Replication Mechanism for Generating Nonrecurrent Rearrangements Associated with Genomic Disorders," describes a newly discovered mechanism for human genomic disorders called replication Fork Stalling and Template Switching (FoSTeS) in which segments of DNA are added or deleted in previously unexpected locations during replication.
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