| 28 September 48 BC | Rome, Egypt, Ptolemaic Kingdom [wars] | The Roman general Pompey the Great is assassinated in Egypt by King Ptolemy XIII of Egypt's troops when he lands at Pelusium, Egypt (57). |
| 28 September 1106 | England, Normandy [wars] | King Henry I of England defeats and captures his brother Robert Curthose, Duke of Normandy, at the Battle of Tinchebrai in Normandy. Robert is imprisoned and Henry becomes Duke of Normandy as well as king of England. |
| 28 September 1322 | Austria, Holy Roman Empire, Bavaria, Germany, Bohemia [wars] | King Ludwig IV of Bavaria is aided by King John I of Bohemia in defeating and capturing Frederick of Austria on the River Inn at Mühldorf, on the Austrian border. |
| 28 September 1347 | France, England [Hundred Years War (1337–1453)] | King Edward III of England makes a truce with King Philip VI of France. |
| 28 September 1362 | Italy [administration] | Guillaume de Grimoard is elected Pope Urban V. |
| 28 September 1822 | France [births and deaths] | Louis Pasteur, French microbiologist who proves that micro-organisms cause disease and fermentation and develops the process of pasteurization, born in Dole, France (–1895). |
| 28 September 1823 | Italy [Catholicism] | After the death of Pope Pius VII on 20 August, the Italian clergyman Annibale Sermattei Della Genga is elected Pope Leo XII. He is pope until 1829. |
| 28 September 1891 | USA [births and deaths] | Herman Melville, US novelist, short-story writer, and poet who wrote Moby Dick, dies in New York City (72). |
| 28 September 1894 | UK [shops and shopping] | Michael Marks and Tom Spencer open their first Penny Bazaar, a stall selling a wide range of domestic products, in Manchester, England.Building on a network of stalls, they open their first Marks & Spencer shop in 1922: this will grow to become Britain's most successful chain of department stores. |
| 28 September 1895 | France [births and deaths] | Louis Pasteur, French microbiologist who proved that micro-organisms cause disease and fermentation and who developed the process of pasteurization, dies in Saint-Cloud, near Paris, France (73). |
| 28 September–31 October 1914 | Poland, Russian Empire [World War I (1914–18)] | German and Austrian forces attack Russian troops south of Warsaw, Poland, in the First Battle of Warsaw, but are driven back. |
| 28 September 1953 | USA [births and deaths] | Edwin Powell Hubble, US astronomer who provided the first proof that the universe is expanding, dies in San Marino, California (63). |
| 28 September 1961 | Syria [revolution] | An army coup in Damascus, Syria, overthrows the government there. On 29 September, Syria secedes from the United Arab Republic and forms the Syrian Arab Republic. |
| 28 September 1970 | Egypt [births and deaths] | Gamal Abdel Nasser, prime minister of Egypt 1954–56 and then president 1956–70, dies in Cairo, Egypt (52). |
| 28 September 2003 | Italy [energy] | A massive power failure across Italy brings the whole country with the exception of Sardinia to a standstill for hours. A breakdown of electricity lines from neighbouring Switzerland and France is thought responsible. |
