Despite the fact that many years' experience of using ZDV and d4T in various combinations have been accumulated, these drugs have been superseded by ABC and TDF in the light of data proving equivalent or greater potency, reduced risk of long-term toxicity and better early tolerability.

Prescribe effective (three-drug) combination therapy whenever: ** indicated for maternal health as per adult guidelines; ** baseline maternal viraemia >10,000 copies/ml; ** baseline maternal viraemia <10,000 copies/ml (as an alternative to ZDV monotherapy plus pre-labour Caesarean section); ** drug resistance detected on genotype/ phenotype.

Box 6416, High Point, NC 27262 Tel: (336) 885-1010 Fax: (336) 885-1011 3 ZTLL 16" - 140" 3 ZMTHL 12" - 20" 3 ZMTH 30" - 120" 3 ZDV 80" - 120" Flying Dutchman Inc.