Zernike, Frits

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Zernike, Frits (1888–1966)

Dutch physicist who was awarded the Nobel Prize for Physics in 1953 for his invention of the phase-contrast microscope in 1935. Earlier microscopes allowed many specimens to be examined only after they had been transformed by heavy staining and other treatment. The phase-contrast microscope allowed living cells to be directly observed by making use of the difference in refractive indices between specimens and medium.

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