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TEMODAL (temozolomide)
Capsule is an oral, cytotoxic alkylating agent indicated for treating
glioblastoma multiforme (GBM). The compounds tested thus far include
N-methyl-N'-nitro-nitrosoguanidine (an alkylating agent similar to
methyl methane sulfonate) and cadmium (a toxic metal found in tap
water). Using these and other factors, the retrospective study of more than
9,000 patients provides strong statistical evidence that approximately
half of the secondary bone cancers observed can be blamed on radiation
therapy or on chemotherapeutic alkylating agents such as the frequently
prescribed cyclophosphamide. |
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