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allopurinol

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allopurinol

Drug mainly prescribed for the treatment of chronic gout; it is an isomer of hypexanthine C5H4N4O, and acts by reducing levels of uric acid in the blood.

Discovered accidentally in the early 1960s in the search for new immunosuppressives, it has no effects on acute gout attacks, and may even provoke them in the initial stages of therapy. In the long term, it prevents the deposit of urates (salts of uric acid) in the joints and the formation of kidney stones.
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At first, relapsed patients were treated with a combination of sodium stibogluconate and allopurinol, which was unsuccessful in contrast with its reported success in Kenya, or with amphotericin deoxycholate (8).
Changing pattern of visceral leishmaniasis, United Kingdom, 1985-2004 by Lockwood, Diana N.J. / Emerging Infectious Diseases
Yet one study showed that when rats were pretreated with allopurinol or superoxide dismutase/polyethylene glycol prior to the induction of ischemia, cochlear action potential thresholds were maintained.
Pharmacologic manipulation of the labyrinth with novel and ... by Water, Thomas R. Van De / Ear, Nose and Throat Journal
If attacks continue and tophi develop, however, the doctor may prescribe medicine to treat hyperuricemia, most commonly allopurinol (Zyloprim) and probenecid (Benemid).
Questions and Answers About Gout by Pamphlet by: Nat'l Inst. of Arthritis and Musculoskeletal & Skin Diseases
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