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glycoside |
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glycoside
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Because monarch caterpillars in the northeastern United States feed mostly on mildly toxic varieties of milkweed, as butterflies they possess few cardiac glycosides -- and therefore are only mildly noxious to their predators. Most patients in the clinical trial supporting effectiveness, referred to as A-HeFT, received, in addition to BiDil or placebo, a loop diuretic, an angiotensin converting enzyme inhibitor or an angiotensin II receptor blocker, and a beta blocker, and many also received a cardiac glycoside or an aldosterone antagonist. While the chemical identity of the inhibitor remained a mystery, the team's data suggested the compound had physiological effects similar to those of a cardiac glycoside called digitalis. |
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