In addition, clinical examination and investigation of these patients showed vasculopathologic changes in the macular region that affected the retinal and choroidal blood vessels (5), although the tissues of the periphery tended to be spared.

unresectable skull base and cervical spine tumors and choroidal melanomas) for which charged-particle therapy is more advantageous than traditional radiotherapeutic techniques.

Anthony Adamis, MD, associate professor of ophthalmology at Harvard Medical School and director of EyeTech's preclinical development program noted, "Given the requisite role of VEGF in ocular neovascularization and the aptamers' high specificity for VEGF, this aptamer is a logical choice for the inhibition of choroidal neovascularization secondary to AMD.