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clot-buster

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clot-buster

Popular term for a small group of thrombolytic (clot-dissolving) drugs used in the treatment of heart attack. See also streptokinase.

Tissue plasminogen activator (tPA) is a natural clot-buster found in the bloodstream. It prevents excess clotting and a synthetic version is used to diperse clots in heart attack victims. Premenopausal women have higher levels of TPA in their blood than men of the same age, but after menopause there is little difference in the levels.

TPA was approved by the US Food and Drug Administration (FDA) for the treatment of strokes caused by blood clots.
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? Mentioned in ? References in periodicals archive
 
One of PAI's main duties in the blood stream is to block the action of the clot-buster tissue blood vessel cells.
Blood substances linked to heart risk by Fackelmann, Kathy A. / Science News
ReoPro has the potential to increase the risk of bleeding, particularly in the presence of anticoagulation such as heparin or a clot-buster.
Data Released at the American College of Cardiology Meeting Support ... by Business Wire
Indeed, the relatively new clot-busters may prove a disadvantage if they are more likely to dissolve beneficial clots in other parts of the bloodstream, such as clots repairing a breach in a brain blood vessel, Hennekens warns.
Sizing up the risks of heart-saving drugs by Fackelmann, Kathy A. / Science News
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