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collagen |
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collagenProtein that is the main constituent of connective tissue. Collagen is present in skin, cartilage, tendons, and ligaments. Bones are made up of collagen, with the mineral calcium phosphate providing increased rigidity. Collagen is made by fibroblast cells that are found in connective tissue. The collagen molecule consists of three protein chains, each about 1,000 amino acids in length, that are entwined in a triple helix. There are 15 known types of collagen that can be divided into fibrillar and nonfibrillar. Fibrillar collagens are found in cartilage, tendons, skin, and bones and the fibrillar structure gives these great strength. Nonfibrillar collagens are found separating the basement membranes, the epithelial layers that line tube and in the cornea. They form networks and sheets. Collagen therapyCollagen is used cosmetically to enhance lips and smooth out wrinkles. The collagen, which is extracted mainly from cow hides, is injected into the skin. For wrinkle treatment it is injected into the dermis over six sessions, which have to be repeated after several months as the implants degrade.
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The stroma of fibrous dysplasia is more collagenous, less vascular, and less cellular than that of ossifying fibroma; the stroma of ossifying fibroma is made up of cellular connective tissue with varying degrees of both osteoblastic and osteoclastic activity. Increased nitric oxide production in collagenous and lymphocytic colitis. The paucity of in vivo studies is in contrast to a number of in vitro studies on the effect of insonation on collagenous tissue extensibility, usually of rat tail tendon. |
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