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twin |
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twinOne of two young produced from a single pregnancy. Human twins may be genetically identical (monozygotic), having been formed from a single fertilized egg that splits into two cells, both of which became implanted. Nonidentical (fraternal or dizygotic) twins are formed when two eggs are fertilized at the same time.
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However, twin studies have consistently shown low rates of concordance (5-8%) in monozygotic and dizygotic twins (Foltynie et al. This estimate is based on studies that compared genetically identical, monozygotic twins to nonidentical, dizygotic pairs, for which the concurrence rate can be as low as 2% to 7% (19). 3) By adding dizygotic (DZ) twins to a similar study setting, exploring genetic versus shared environmental influences, the components of familial aggregation would be possible. |
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