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endotoxin
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endotoxin

In biology, heat stable complex of protein and lipopolysaccharide that is produced following the death of certain bacteria. Endotoxins are typically produced by the Gram negative bacteria and can cause fever. They can also cause shock by rendering the walls of the blood vessels permeable so that fluid leaks into the tissues and blood pressure falls sharply.


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Mice deficient for the 55 kDa tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L monocytogenes infection.
89 93 Other potential therapeutic roles of NO include the treatment of endotoxic shock, adult respiratory distress syndrome, and hypertension in various disease states such as atherosclerosis and chronic renal failure.
Striking anti-inflammatory effects were demonstrated with IRHs in in vivo models of pleurisy (a model of lung inflammation), EAE (experimental autoimmune encephalomyelitis, a model of multiple sclerosis) and LPS challenge (lipopolysaccharide, a lethal model of endotoxic shock).
 
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