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prostacyclin
(redirected from Epoprostenol)

    Also found in: Medical, Wikipedia 0.03 sec.

prostacyclin

In medicine, a prostaglandin that is produced by the endothelial lining of the blood vessels. It inhibits the aggregation of platelets in the cardiovascular system and, consequently, the formation of blood clots. It is also a potent vasodilator, causing blood vessels to dilate.

Prostacyclin, either alone or in combination with heparin, is used to inhibit platelet aggregation in patients undergoing renal dialysis. It has to be given by continuous intravenous infusion because its half-life is only three minutes. Adverse effects include flushing, hypotension, and headache because of its activity as a vasodilator.



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33) IV epoprostenol appears to have the best effects in this regard.
Pulmonary arterial hypertension: evaluation and management by Waxman, Aaron B. / Southern Medical Journal
She responded very well to IV epoprostenol with improved functional capacity and 6MW.
Long-term results after addition of sildenafil in idiopathic PAH ... by Arroliga, Alejandro C. / Southern Medical Journal
The patient was initially given Ca-channel blocker without any significant response therefore epoprostenol was administered incremental doses up to 14 nanogram per minute, at which pulmonary artery pressure began to decrease significantly (60/35).
MED-22. Successful use of eporpostenol in the treatment of SLE ... by Rahman, Rashid / Southern Medical Journal
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