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tamoxifen |
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tamoxifen
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Preclinical studies indicated that arzoxifene is an estrogen agonist in bone and on lipids, but an estrogen antagonist in endometrial and breast tissue. Selective estrogen receptor modulators (SERMs) are a structurally diverse group of compounds that interact with the estrogen receptor to elicit either an estrogen agonist or an estrogen antagonist response, depending on the target tissue and physiologic context Even though ICI 182,780 is recognized as a potent estrogen antagonist and it depressed MMP-13 promoter activity by ~69% when ER[alpha] was present (Lu et al. |
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