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tamoxifen
(redirected from estrogen antagonist)

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tamoxifen

Oestrogen-blocking drug used to treat breast cancer and also infertility. It kills cancer cells by preventing formation of the tiny blood vessels that supply the tumour. Without a blood supply the tumour shrinks as its cells die. Side effects include hot flushes, skin rashes, vaginal discharge, and more rarely, endometrial cancer. Trials have shown that it may also prevent breast cancer in healthy women with a family history of the disease.



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? Mentioned in ? References in periodicals archive
 
The estrogen antagonist ICI 164384, for example, attenuates the effects of cadmium on gene expression.
Understanding sex differences in environmental health: a thought ... by Marts, Sherry A. / Environmental Health Perspectives
57-63-6), and the reference estrogen antagonist was the pure antagonist ZM 189,154 (ZM; CAS no.
The OECD program to validate the rat uterotrophic bioassay to screen ... by Owens, William / Environmental Health Perspectives
However, we cannot rule out that newly identified receptors such as SXR and PXR [reviewed by Blumberg and Evans (62)], which are activated by a variety of different compounds, including estrogen antagonists and agonists, could be involved in the activation/repression of some of the estrogen-sensitive genes we have identified.
Assaying Estrogenicity by Quantitating the Expression Levels of ... by Leffers, Henrik / Environmental Health Perspectives
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