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tamoxifen
(redirected from estrogen antagonist)

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tamoxifen

Oestrogen-blocking drug used to treat breast cancer and also infertility. It kills cancer cells by preventing formation of the tiny blood vessels that supply the tumour. Without a blood supply the tumour shrinks as its cells die. Side effects include hot flushes, skin rashes, vaginal discharge, and more rarely, endometrial cancer. Trials have shown that it may also prevent breast cancer in healthy women with a family history of the disease.



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? Mentioned in ? References in periodicals archive
 
Preclinical studies indicated that arzoxifene is an estrogen agonist in bone and on lipids, but an estrogen antagonist in endometrial and breast tissue.
Arzoxifene for Prevention of Osteoporosis by OB/GYN Clinical Alert
Selective estrogen receptor modulators (SERMs) are a structurally diverse group of compounds that interact with the estrogen receptor to elicit either an estrogen agonist or an estrogen antagonist response, depending on the target tissue and physiologic context
Selective Estrogen Receptor Modulators by Ricky Hussey / Health, general community
Even though ICI 182,780 is recognized as a potent estrogen antagonist and it depressed MMP-13 promoter activity by ~69% when ER[alpha] was present (Lu et al.
Evidence that estrogen receptor [beta] enhances MMP-13 promoter ... by Lu, Ting; Achari, Yamini; Rattner, Jerome B.; Hart, David A. / Biochemistry and Cell Biology
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