estrogen antagonist - Hutchinson encyclopedia article about estrogen antagonist Printer Friendly
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tamoxifen
(redirected from estrogen antagonist)

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tamoxifen

Oestrogen-blocking drug used to treat breast cancer and also infertility. It kills cancer cells by preventing formation of the tiny blood vessels that supply the tumour. Without a blood supply the tumour shrinks as its cells die. Side effects include hot flushes, skin rashes, vaginal discharge, and more rarely, endometrial cancer. Trials are under way to investigate its potential for preventing breast cancer in healthy women with a family history of the disease.


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The estrogen antagonist ICI 164384, for example, attenuates the effects of cadmium on gene expression.
57-63-6), and the reference estrogen antagonist was the pure antagonist ZM 189,154 (ZM; CAS no.
However, we cannot rule out that newly identified receptors such as SXR and PXR [reviewed by Blumberg and Evans (62)], which are activated by a variety of different compounds, including estrogen antagonists and agonists, could be involved in the activation/repression of some of the estrogen-sensitive genes we have identified.
 
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