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ex vivo

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ex vivo

Outside of the living body. In analogy to in vitro (in the test tube) and in vivo (in the living organism), ex vivo is used to describe procedures which involve removing cells, tissues, or organs from the living organism for treatment, manipulation, or analysis, and then returning them.

In gene therapy, for example, ex vivo describes a technique used in which genetically defective cells are removed and cultured in vitro. After growth, normal genes are added to the cells to correct the defect. These modified cells are next returned to the donor.



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Currently, ex vivo gene therapy is expanding throughout the world as an effective treatment method for several incurable diseases.
8 million from the Dutch Ministry of Economic Affairs for the pre- clinical development of ex vivo gene therapy using interleukin-10 (IL-10) in patients suffering from Crohn's disease.
The ex vivo testing phase began several weeks after the sheep were sacrificed.
 
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