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fibrin
(redirected from fibrinogen)

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fibrin

Insoluble protein involved in blood clotting. When an injury occurs fibrin is deposited around the wound in the form of a mesh, which dries and hardens, so that bleeding stops. Fibrin is developed in the blood from a soluble protein, fibrinogen.

The conversion of fibrinogen to fibrin is the final stage in blood clotting. Platelets, a type of cell found in blood, release the enzyme thrombin when they come into contact with damaged tissue, and the formation of fibrin then occurs. Calcium, vitamin K, and a variety of enzymes called factors are also necessary for efficient blood clotting.



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Consistent with this hypothesis clinical studies demonstrate that periodontitis patients have elevated markers of systemic inflammation, such as C-reactive protein (CRP), interleukin 6 (IL-6), haptoglobin, and fibrinogen.
It was found that obese children had a 10 fold higher CRP and significantly higher fibrinogen concentrations, compared with age- and sex-matched lean children.
Other blood parameters indicative of acute inflammation likewise decreased with Pycnogenol, such as fibrinogen (lowered 37%) and reactive oxygen species (lowered by 30%).
 
 
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