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In a state of chronic inflammation, glial cells "get excited and work against the system," she says. To this end, the ER-negative glial cell line U251-MG was transfected with the three zebrafish ER subtypes and the Aro-B promoter linked to a luciferase reporter gene. Amgen halted tests of GDNF, shorthand for glial cell line-derived neurotrophic factor drug, on 48 patients last year after more than a year of tests. |
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