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glycolysis |
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glycolysis
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Lactate dehydrogenase (LDH) is the last enzyme of the glycolytic pathway and catalyzes the conversion of pyruvate to lactate (forward; LDHf) or lactate to pyruvate (reverse; LDHr). When oxygenation reaches low critical levels, conservative strategies favor reversible inhibition of the glycolytic pathway, coupled with additional substrate-level phosphorylations (Hochachka & Somero 2002). Common sense dictates that without proper blood flow, there will not be efficient delivery of oxygen to tissues, and without oxygen, tissues are forced through glycolytic pathways to maintain function. |
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