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graft-versus-host disease

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graft-versus-host disease

Complication of bone-marrow transplant where the grafted bone marrow attacks its host. In its mildest form patients develop a skin rash, but gut and liver inflammation can occur in more severe forms.

GVHD occurs in more than a third of patients receiving transplants from siblings. Its incidence is higher where donors are unrelated. Once established GHVD has a mortality rate of between 10 and 30%.
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On the other hand, both studies show that mismatched cord-blood transplants are less apt to spawn acute attacks of graft-versus-host disease than mismatched marrow is.
Umbilical bounty: cord blood shows value against leukemia by Seppa, N. / Science News
Five days after cessation of the iHg injections, both case and control mice were intravenously administered spleen cells from another mouse strain to induce chronic graft-versus-host disease (GVHD), a well-established murine model of acquired autoimmunity.
Setting the stage for illness: mercury exposure and autoimmune disease by Hood, Ernie / Environmental Health Perspectives
Biohybrid's product platform of hybrid antibodies and genetically engineered vectors are agents for the treatment of graft rejection, graft-versus-host disease, and autoimmune disorders.
BIOHYBRID GETS ANOTHER MILESTONE PAYMENT FROM MICROMET GMBH by Worldwide Biotech
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