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graft-versus-host disease

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graft-versus-host disease

Complication of bone-marrow transplant where the grafted bone marrow attacks its host. In its mildest form patients develop a skin rash, but gut and liver inflammation can occur in more severe forms.

GVHD occurs in more than a third of patients receiving transplants from siblings. Its incidence is higher where donors are unrelated. Once established GHVD has a mortality rate of between 10 and 30%.



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? Mentioned in ? References in periodicals archive
 
On the other hand, both studies show that mismatched cord-blood transplants are less apt to spawn acute attacks of graft-versus-host disease than mismatched marrow is.
Five days after cessation of the iHg injections, both case and control mice were intravenously administered spleen cells from another mouse strain to induce chronic graft-versus-host disease (GVHD), a well-established murine model of acquired autoimmunity.
Biohybrid's product platform of hybrid antibodies and genetically engineered vectors are agents for the treatment of graft rejection, graft-versus-host disease, and autoimmune disorders.
 
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