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Although the clinical potential of the NDW in the differential diagnosis of the several conditions associated with leukocytosis still remains to be investigated, our study has already demonstrated at least 1 important use of the NDW: as an additional discriminator for septicemic patients who have otherwise unremarkable hematologic profiles. In contrast, systemic changes marked by alterations in the hematologic profile may be a more sensitive indicator of particle-related biologic responses, which could be potentially linked to cardiac effects (48). During the Phase II study, ICA-17043 was demonstrated to improve the hematologic profile in patients with sickle cell anemia. |
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