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hepatic |
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hepatic
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In the eight serious reports to the TGA some patients had not improved after drug cessation due to the severity of hepatic injury. The ratio of the relative increase of the measured values over the upper normal limit of ALT (40 IU/L) to that of ALP (120 IU/L) was > 5 in all cases, indicating that the hepatic injury was primarily hepatocellular rather than cholestatic. Two well-known dose-related side effects of CYC are bone marrow suppression and hepatic injury. |
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