If subtype specificity does exist, the independent effect of early smoking on lung cancer would be considerably more difficult to detect in the many epidemiologic studies that have grouped different histologies together.

Leibenhaut et al studied 915 patients with clinical stage (CS) I and II Hodgkin's disease who underwent laparotomy, and they were able to identify specific subgroups in whom laparotomy had a low yield [14] These patients included women with CS I disease, patients with mediastinum-only CS I disease, and men with CS I disease who had either lymphocyte predominance or interfollicular histologies.

The combined activity of Targretin and Taxol was synergistic and the observed effects were seen across a panel of 10 different NSCLC cell lines representative of different tumor histologies seen in NSCLC patients.