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immunosuppressive |
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immunosuppressiveAny drug that suppresses the body's normal immune responses to infection or foreign tissue. It is used in the treatment of autoimmune disease (see autoimmunity); as part of chemotherapy for leukaemias, lymphomas, and other cancers; and to help prevent rejection following organ transplantation. Immunosuppressed patients are at greatly increased risk of infection. |
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| Generally, steroid hormones are implicated in the immune response, with estrogens as enhancers at least of the humoral immunity and androgens, progesterone, and glucocorticoids as natural immunosuppressors (Cutolo et al. The ATD have some immunosuppressor effects, (7-9) but it is less probable that these drugs could be active many years after discontinuation of the therapy. Information on immunosuppression was obtained for patients with a history of cancer, organ transplants, splenectomy, HIV infection (when the CD4+ T-cell count was <200 cells/[micro]L), and immunosuppressor or steroid treatment ([greater than or equal to] 0. |
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