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kernicterus

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kernicterus

In medicine, brain damage associated with haemolytic disease of the newborn.

An incompatibility between the blood groups of mother and baby cause the baby's red blood cells to break down resulting in high concentrations of bilirubin (a pigment derived from haemoglobin) in the blood. Some of this bilirubin enters the brain causing toxic degeneration of the brain cells. Concentrations of bilirubin in the blood serum of affected infants with haemolytic disease should be monitored so that treatment can begin before dangerous concentrations are reached. Treatment is with blood transfusion, and can be administered before birth (see fetal therapy).



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[42] Because of the possibility of kernicterus (associated with sulfonamide therapy), silver sulfadiazine should be avoided during pregnancy, on premature infants, or on infants younger than 2 months of age.
The Sheridan family experienced another healthcare system failure when their son Cal's neonatal jaundice went untreated, leading to a kind of severe brain damage called kernicterus.
Sheridan, President of Parents of Infants and Children with Kernicterus (PICK) to testify at an Advisory Committee meeting on the current epidemiology and therapeutic interventions relevant to hyperbilirubinemia in the term and near-term newborn on Wednesday, June 11, 2003.
 
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