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base pair
(redirected from Kilobase)

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base pair

In biochemistry, the linkage of two base (purine or pyrimidine) molecules that join the complementary strands of DNA. Adenine forms a base pair with thymine (or uracil in RNA) and cytosine pairs with guanine in a double-stranded nucleic acid molecule.

One base lies on one strand of the DNA double helix and one on the other, so that the base pairs link the two strands like the rungs of a ladder. In DNA, there are four bases: adenine and guanine (purines) and cytosine and thymine (pyrimidines). Adenine always pairs with thymine and cytosine with guanine.

The sizes of genes and genomes are commonly cited in base pairs, for example the human genome consists of around 3 billion base pairs.



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? Mentioned in ? References in periodicals archive
 
CNVs can consist of deletions, duplications or multi-site variants in DNA segments, ranging from a few kilobases to megabases in length.
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Visualization of human chromosomes has been relatively common, however commercially available FISH probes, covering 100 to 300 kilobases, or 100,000 to 300,000 DNA bases, have been too large for their targeted DNA.
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The project involved sequencing several hundred kilobases of DNA, including all coding and regulatory regions, from 25 persons of diverse racial and ethnic backgrounds.
Interleukin Genetics Announces Completion of SNP Discovery in Key ... by Business Wire
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