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metastasis
(redirected from Metastatic cancer)

   Also found in: Medical, Legal, Encyclopedia, Wikipedia 0.20 sec.

metastasis

Spread of a malignant tumour from its original site. During metastasis, tumour cells become detached and enter blood or lymphatic vessels, travelling to other parts of the body. The pattern of the spread can be predicted to a certain degree because of this: many cancers spread to the lungs where most deoxygenated blood is returned, whereas intestinal cancers usually spread first to the liver.



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and tissue biopsies of the lymph nodes revealed that 20 of them had metastatic cancer and 30 of them had cancer that remained localized at the time of surgery.
He says that such autopsy studies of metastatic cancer can provide a molecular catalogue of cellular defects specific to individuals and general groups.
One of the few consistent features across all types of cancer is the dramatic increase in glucose uptake by metastatic cancer cells compared with their normal counterparts, reflecting an increased rate of glycolysis and a decrease in acetyl co-enzyme A, the substrate for mitochondrial oxidative phosphorylation.
 
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