In a study of the relationship between scores on masculine gender role stress and blood pressure reactivity, men exposed to the cold pressor test (in which hands are submerged in ice cold water) were given either neutral instructions (in which they were told they were simply providing physiological data) or masculine challenge instructions (in which they were told that exposure of their hands in ice cold water was a measure of strength, endurance and ability to withstand pain).

First, it confirmed that methadone-maintained patients demonstrated hyperalgesia and not allydonia when pain sensitivity was measured with the cold pressor test.

6,10) The use of epinephrine or other pressor ammines can cause a hypertensive crisis in a patient with uncontrolled hyperthyroidism.