This edition has new material on the behavior of zebra fish and Caenorhabditis elegans, the relevance of transgenic mouse models for Alzheimer's disease, behavioral methods for assessing the cognitive impairment associated with major psychotic disorders, the revival of the scopolamine reversal model for assessing the clinical relevance of new AD drugs, and new approaches to assessing cognitive impairment in aged mice and mice impaired as a consequence of high cerebral amyloid burden.

Robert House, an obstetrician who noticed that the popular obstetric anesthetic drug, scopolamine, would put his patients into a state where they would deliver information in a way that seemed automatic.

In fact, their learning and memory abilities were noticeably unaffected by scopolamine as compared with the different treatments, as well as other control groups, such as SB-PS, fish oil or a mixture of SB-PS and fish oil.